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This is generally achieved using large, cryo-cooled superconducting magnets, causing NMR instrumentation to become so large that it generally requires a dedicated facility, whereas many other analytical instruments can be handled readily and placed on a nearby workbench in a chemistry laboratory ( Figure 1). Here we discuss some recent progress in inexpensive custom NMR instrumentation, potential new applications, and perspectives for the future.įor many decades, advances in NMR spectroscopy and to some extent medical MRI have focused on achieving high magnetic fields in order to improve both sensitivity and resolution.

At the same time, increased availability of inexpensive electronic controllers and 3D printing technology present new opportunities for innovation in other NMR applications. Many recent developments in NMR, notably significant advances in applications to structural biology and materials science and the concomitant push to develop expensive high-field instrumentation, have encouraged standardization and the use of commercial equipment. As this early history illustrates, the magnetic resonance community is at its most vibrant and innovative when researchers with different interests and areas of expertise freely share information. Many senior members have fond memories of experimenting with Heathkits, perusing the supplies at Radio Shack and Fry’s Electronics, and chatting with far-flung amateur radio operators in a forerunner of today’s online maker spaces. The magnetic resonance community has a strong tradition of instrumentation design, with an emphasis on targeted design of instruments that enable particular experimental advances. This interaction, facilitated in particular by John Roberts at Caltech established the utility of NMR for studying complex organic molecules. During the following years, the Varian Applications Lab, led by Jim Shoolery, played an important role in facilitating communication between instrument builders, both at Varian and in academia, and chemists who provided feedback on what kinds of advances would most impact their work. The first commercial NMR spectrometer was produced by Russell and Sigurd Varian, following very quickly after the initial discoveries of condensed matter nuclear magnetic resonance by Bloch and Purcell, who were mostly interested in exploring the underlying physics rather than applications to chemistry.

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